On 12 February 2012, Ronaldo scored a hat-trick, his thirteenth in La Liga and fourteenth for Real Madrid in a 4–2 home win over Levante. This win stretched Real Madrid's lead over second-placed Barcelona to 10 points.

On 24 March 2012, Ronaldo reached more than 100 goals in La Liga in just three seasons at Real Madrid when he scored the first of his two goals in the match against Real Sociedad, the second quickest La Liga player to reach that milestone in the league afterIsidro Lángara, reaching the milestone in 92 matches and breaking the previous club record held by Puskás.^[120] As of 24 March 2012, Ronaldo had averaged 1.01 goals per game in La Liga.

On 11 April, Ronaldo scored a hat-trick against Atletico Madrid in a 1–4 win, as well as assisting the last goal. His hat-trick, one goal from a free kick, one from 30 yards on the left wing and one penalty, gave him 40 league goals in the season, making him the only player in La Liga history, or in any other major European league, to score 40 goals in two seasons, even doing so in consecutive seasons. Ronaldo officially broke his previous record of 40 goals in a La Liga season on 14 April, scoring in a 3–1 win against Sporting Gijón. On 25 April, in the second leg of the semi-finals in the 2011–12 UEFA Champions League against Bayern Munich, Ronaldo converted a penalty from a David Alaba handball and scored a second goal from a pass from Mesut Özil. Extra time ended with the tie level at 3–3, and Real Madrid were eliminated in the shootout with Ronaldo's kick being saved by Manuel Neuer.^[121]

On 13 May 2012, the last matchday, Ronaldo scored against Mallorca which made him the first player ever to score against every team in a single season in La Liga.^[17] He ended his third season at Real Madrid by winning his first league title with the club, with a record 100 points, notching a total of 46 league goals and 60 goals in all competitions, breaking the Real Madrid record he had set the previous season.